Bovine enzootic haematuria from consumption of Pteris deflexa and Pteris plumula in northwestern Argentina

• Published in: Toxicon (Oxford) Vol. 134; pp. 26 - 29
• Main Authors: Micheloud, Juan Francisco, Colque-Caro, Luis Adrián, Martinez, Olga Gladys, Gimeno, Eduardo Juan, da Silva Freitas Ribeiro, Debora, Blanco, Benito Soto
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2017
• Subjects: Animals; Argentina; Carcinogens - isolation & purification; Cattle; Cattle Diseases - etiology; Enzootic haematuria; Fern poisoning; Hematuria - chemically induced; Hematuria - veterinary; Indans - isolation & purification; Plant Poisoning - veterinary; Ptaquilosides; Pteris - chemistry; Pteris - poisoning; Pteris spp; Sesquiterpenes - isolation & purification; Urinary Bladder Neoplasms - chemically induced; Pteris spp; Enzootic haematuria; Fern poisoning; Ptaquilosides
• ISSN: 0041-0101; 1879-3150
• DOI: 10.1016/j.toxicon.2017.05.023

Bovine enzootic haematuria (BEH) is caused by prolonged ingestion of toxic principles of bracken fern, essentially by Pteridium spp. In northwestern Argentina, this disease has a great economic impact ant it is attributed a chronic consumption to Pteridium arachnoideum. This paper describes two endemic areas for enzootic hematuria due to the consumption of Pteris deflexa and Pteris plumula. Two areas where P. deflexa and P. plumula are endemic, but free of Pteridium species, were devised and seven farms were visited. The disease was confirmed based on the presence of clinically affected animals. In four necropsies bleeding neoplastic lesions were observed in the mucosa of the urinary bladder. At phytochemical analysis, both ptaquiloside and pterosin B were found in P. deflexa and P. plumula. Thus, the consumption of P. deflexa and P. plumula can also cause BEH. •Bovine enzootic haematuria is a very important disease in Northwestern Argentina.•Consumption of ptaquiloside-containing Pteridium spp. is a known cause of enzootic haematuria.•Pteris deflexa and Pteris plumula can induce this disease in some regions.•Toxic levels of ptaquiloside was identified in both species.