Giant Primary Neuroendocrine Neoplasms of the Liver: Report of 2 Cases With Molecular Characterization

Primary neuroendocrine neoplasms of the liver have occasionally been reported in the liver, though many reports do not convincingly exclude metastases. In this article, we report 2 "giant" hepatic neuroendocrine lesions without evidence of a primary elsewhere after clinical workup. One occ...

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Bibliographic Details
Published inInternational journal of surgical pathology Vol. 27; no. 8; p. 893
Main Authors Pastrián, Laura G, Ruz-Caracuel, Ignacio, Gonzalez, Raul S
Format Journal Article
LanguageEnglish
Published United States 01.12.2019
Subjects
neuroendocrine neoplasms
liver
metastasis
molecular testing
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Summary:Primary neuroendocrine neoplasms of the liver have occasionally been reported in the liver, though many reports do not convincingly exclude metastases. In this article, we report 2 "giant" hepatic neuroendocrine lesions without evidence of a primary elsewhere after clinical workup. One occurred in a 21-year-old male; the lesion was a large cell neuroendocrine carcinoma measuring 24 cm. The patient died of disease in 10 months. The other occurred in a 25-year-old patient, was 18 cm wide, and was diagnosed as a well-differentiated neuroendocrine tumor, World Health Organization grade 3. The patient died of disease after 30 months. Molecular testing demonstrated only the presence of mutations in common. These cases expand our knowledge of seemingly primary neuroendocrine neoplasms of the liver, in particular, giant cases measuring more than 8 cm. Guidelines for clinical workup and therapy for these lesions remain unclear, but future thorough workup of such cases is necessary for specific characterization.
ISSN:1940-2465
DOI:10.1177/1066896919855764