Does psychological resilience buffer against the link between the 5-HTTLPR polymorphism and depression following stress
The comparative strength of the 5-HTTLPR polymorphism as a ‘predictor’ of depression after major stress, versus the ‘protective’ effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatme...
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Published in | Physiology & behavior Vol. 180; pp. 53 - 59 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
15.10.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The comparative strength of the 5-HTTLPR polymorphism as a ‘predictor’ of depression after major stress, versus the ‘protective’ effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression. These data suggest that the carriage of the short form of the 5-HTTLPR may negate the protective effect of PR against depression in these men, or that PR may nullify the depression vulnerability of this form of the 5-HTTLPR. These findings may explain some of the ‘null’ findings regarding the link between the 5-HTTLPR and depression in the wider literature by arguing for an interaction between these two factors in the association between major stress and depression.
•5-HTTLPR has been inconsistently associated with depression after stress.•Psychological resilience (PR) may have a protective effect against depression.•Men with prostate cancer often become depressed.•PR interacts with 5-HTTLPR to reduce stress-related depression in these men. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0031-9384 1873-507X |
DOI: | 10.1016/j.physbeh.2017.07.029 |