Are biosensor arrays in one membrane possible? A combination of multifrequency impedance measurements and chemometrics

A novel concept of a membrane-based micro-array biosensor is presented. The methodology is based on a single lipid membrane interrogated with electrochemical impedance techniques followed by multivariate data analysis. A single membrane is designed so that relaxation processes with a range of time c...

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Bibliographic Details
Published inAnalytical and bioanalytical chemistry Vol. 377; no. 3; pp. 478 - 485
Main Authors Lindholm-Sethson, Britta, Nyström, Josefina, Geladi, Paul, Koeppe, Roger, Nelson, Andrew, Whitehouse, Conor
Format Journal Article
LanguageEnglish
Published Germany 01.10.2003
Subjects
Biosensing Techniques - methods
Electrochemistry
Gramicidin - chemistry
Lipid Bilayers - chemistry
Membrane Potentials
Metals - chemistry
Multivariate Analysis
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Summary:A novel concept of a membrane-based micro-array biosensor is presented. The methodology is based on a single lipid membrane interrogated with electrochemical impedance techniques followed by multivariate data analysis. A single membrane is designed so that relaxation processes with a range of time constants can be probed at different potentials. A range of other approaches cited in the literature is reviewed.
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ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-003-2103-y