PARP-1 rs3219073 polymorphism may contribute to susceptibility to lung cancer

• Published in: Genetic testing and molecular biomarkers Vol. 18; no. 11; p. 736
• Main Authors: Wang, He-Tong, Gao, Ya, Zhao, Yu-Xia, Yu, Hong, Wang, Tian-Lu, Bai, Lu, Chen, Yan-Zhi, Zhang, Hai-Bo, Zhou, Bao-Sen, Qu, Yan-Li, Liu, Dan, Chen, Ying
• Format: Journal Article
• Language: English
• Published: United States 01.11.2014
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adult; Aged; Alleles; Base Composition; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Middle Aged; Neoplasm Proteins - genetics; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases - genetics; Polymorphism, Genetic
• ISSN: 1945-0257
• DOI: 10.1089/gtmb.2014.0106

To investigate the relationship between the PARP-1 rs3219073 C>G polymorphism and susceptibility to lung cancer in Chinese people. In accordance with the case-control study principle, 645 of the patients had histologically recognized primary lung cancer, among them 240 had squamous carcinoma, 217 had adenocarcinoma, and 188 had small-cell lung cancer. The control group consisted of 643 healthy subjects who had received a physical examination. Extracts of peripheral blood were taken from all subjects, and genomic DNA was extracted by the phenol-chloroform method. After adjusting for age and smoking status, the results show significant association between genetic variations in the rs3219073 C/C genotype and an increased risk of lung cancer (p=0.045, odds ratio [OR]=0.625). After combining C/G, G/G is still statistically significant (p=0.042, OR=0.637). Hierarchical analysis found that the number of subjects with a G/G genotype in the adenocarcinoma group is lower than in the control group (p=0.015, OR=0.543). After combining C/G, G/G is still statistically significant (p=0.027, OR=0.595). After correcting for age and smoking status, the group with C/G genotype and the group with G/G genotype both appear to have a reduced risk for lung cancer compared with the control group (p=0.045, OR=0.566; p=0.013, OR=0.489). The combination of C/G and G/G displays a more statistically significant difference (p=0.018, OR=0.528). The study found that PARP-1 rs3219073 C>G polymorphism is indeed associated with lung cancer susceptibility. The carriers of G alleles may have reduced risk of lung cancer, especially adenocarcinoma.