The role of complement regulatory proteins in peripheral blood cells of patients with systemic lupus erythematosus: Review

• Published in: Cellular immunology Vol. 277; no. 1-2; pp. 1 - 7
• Main Authors: Alegretti, Ana Paula, Schneider, Laiana, Piccoli, Amanda Kirchner, Xavier, Ricardo Machado
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2012
• Subjects: Antigen-Antibody Complex - immunology; Antigens, CD - immunology; Blood Cells - immunology; CD35; CD46; CD55; CD59; Complement; Complement System Proteins - immunology; Female; Humans; Lupus Erythematosus, Systemic - immunology; Male; Systemic lupus erythematosus (SLE); Systemic lupus erythematosus (SLE); CD59; Complement; CD35; CD46; CD55
• ISSN: 0008-8749; 1090-2163
• DOI: 10.1016/j.cellimm.2012.06.008

► The research of our group focuse on studying. ► The density of membrane Cregs proteins CD55, CD59, CD46 and CD35 on cells from Lupus patients. ► The correlation with the deficiency of membrane Cregs proteins and cytopenia. ► The correlation with the deficiency of membrane Cregs proteins and the Lupus disease activity. CD55, CD59, CD35 and CD46 are cell membrane proteins that have regulatory properties on the activation of the complement cascade. Deficiency in the expression of these proteins may be associated with lower protection of healthy cells against complement mediated lysis and also with the accumulation of immune complexes in tissues. Few studies assess the expression of these proteins in patients with SLE and the mechanisms that regulate reduction in cellular expression, whereas its impact on manifestations of systemic lupus erythematosus is still unknown.