Pharmacokinetics of a recombinant bovine growth hormone and pituitary bovine growth hormone in lactating dairy cows

• Published in: Journal of animal science Vol. 71; no. 5; p. 1219
• Main Authors: Toutain, P.L. (INRA, Toulouse, France), Schams, D, Laurentie, M.P, Thomson, T.D
• Format: Journal Article
• Language: English
• Published: United States 01.05.1993
• Subjects: Animals; Cattle - metabolism; DISPONIBILIDAD DE NUTRIENTES; DISPONIBILITE D'ELEMENT NUTRITIF; FARMACOLOGIA; Female; Growth Hormone - administration & dosage; Growth Hormone - pharmacokinetics; Half-Life; HORMONAS PITUITARIAS; HORMONAS SINTETICAS; HORMONE HYPOPHYSAIRE; HORMONE SYNTHETIQUE; INJECTION; Injections, Intravenous - veterinary; INYECCION; Lactation - metabolism; PHARMACOLOGIE; Recombinant Proteins - administration & dosage; Recombinant Proteins - pharmacokinetics; SOMATOTROPINA; SOMATOTROPINE; VACAS LECHERAS; VACHE LAITIERE

The disposition of pituitary-derived bovine growth hormone (pbST) and of a recombinant bovine growth hormone (rbST) produced by Lilly (somidobove, USAN) were compared after an intravenous bolus administration (36.69 micrograms/kg for pbST and 35 micrograms/kg for rbST) to eight lactating cows in a c...