Pharmacokinetics of a recombinant bovine growth hormone and pituitary bovine growth hormone in lactating dairy cows

• Published in: Journal of animal science Vol. 71; no. 5; p. 1219
• Main Authors: Toutain, P.L. (INRA, Toulouse, France), Schams, D, Laurentie, M.P, Thomson, T.D
• Format: Journal Article
• Language: English
• Published: United States 01.05.1993
• Subjects: Animals; Cattle - metabolism; DISPONIBILIDAD DE NUTRIENTES; DISPONIBILITE D'ELEMENT NUTRITIF; FARMACOLOGIA; Female; Growth Hormone - administration & dosage; Growth Hormone - pharmacokinetics; Half-Life; HORMONAS PITUITARIAS; HORMONAS SINTETICAS; HORMONE HYPOPHYSAIRE; HORMONE SYNTHETIQUE; INJECTION; Injections, Intravenous - veterinary; INYECCION; Lactation - metabolism; PHARMACOLOGIE; Recombinant Proteins - administration & dosage; Recombinant Proteins - pharmacokinetics; SOMATOTROPINA; SOMATOTROPINE; VACAS LECHERAS; VACHE LAITIERE
• ISSN: 0021-8812; 1525-3163
• DOI: 10.2527/1993.7151219x

The disposition of pituitary-derived bovine growth hormone (pbST) and of a recombinant bovine growth hormone (rbST) produced by Lilly (somidobove, USAN) were compared after an intravenous bolus administration (36.69 micrograms/kg for pbST and 35 micrograms/kg for rbST) to eight lactating cows in a crossover study. It was shown that dose-dependent parameters (volume of distribution, clearance) were significantly different between the two test articles. The steady mean state volume of distribution (.10 +/-.018 vs 0.12 +/-.015 L/kg) and clearance (.119 +/-.012 vs.143 +/-.011 L. kg-1. h-1) were lower for the pbST than for the somidobove. In contrast, the mean (+/- SD) residence times were not different for the two test articles (50.0 +/- 8.6 vs 46.9 +/- 5.9 min for pbST and somidobove, respectively). The origin of the difference is unclear, but it cannot be explained by the slight difference between the administered dose of the two test articles ( 5%) because the actual dose rate was used to calculate all dose-dependent parameters