Circulating CD4+PD-1+ and CD8+PD-1+ T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+ regulatory T cells

Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We...

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Published inDiabetes research and clinical practice Vol. 133; pp. 10 - 12
Main Authors Iijima, Toshie, Kato, Kanako, Jojima, Teruo, Tomotsune, Takanori, Fukushima, Maiko, Suzuki, Kunihiro, Aso, Yoshimasa
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.11.2017
Subjects
Aged
CD4 Antigens - immunology
CD8 Antigens - immunology
Diabetes Mellitus, Type 1 - metabolism
Female
Humans
Male
Programmed Cell Death 1 Receptor - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We demonstrated that circulating both CD4+PD-1+ and CD8+PD-1+ T cells were profoundly reduced at the onset of fulminant T1D and were restored by treatment in two patients with fulminant T1D.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.07.036