Phytostilbenes in lymphoma: Focuses on the mechanistic and clinical prospects of resveratrol, pterostilbene, piceatannol, and pinosylvin

• Published in: Leukemia research Vol. 138; p. 107464
• Main Authors: Goleij, Pouya, Sanaye, Pantea Majma, Babamohamadi, Mehregan, Tabari, Mohammad Amin Khazeei, Amirian, Roshanak, Rezaee, Aryan, Mirzaei, Hamed, Kumar, Alan Prem, Sethi, Gautam, Sadreddini, Sarvin, Jeandet, Philippe, Khan, Haroon
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2024
• Subjects: Activating immune system; Apoptosis; Clinical application; Lymphoma; Molecular mechanisms; Phytostilbenes; Activating immune system; Clinical application; Lymphoma; Phytostilbenes; Molecular mechanisms; Apoptosis
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2024.107464

Lymphoma is a cancer affecting the lymphatic system that fights infections and diseases. In addition to surgery, radiotherapy, and chemotherapy, novel approaches have recently been investigated, such as phytostilbenes in treating lymphoma. Phytostilbenes are natural compounds present in various plants and have been shown to have different therapeutic effects, including anticancer properties. Resveratrol is a main phytostilbene with various derivates followed by pterostilbene and piceatannol. Studies have revealed that phytostilbenes can suppress the growth and proliferation of lymphoma cells by inducing apoptosis and inhibiting specific enzyme activity in cancer cell survival. The compounds also have antiinflammatory effects contributing to reducing lymphoma-associated inflammation. Additionally, phytostilbenes have been shown to increase the immune system's ability to fight cancer cells by activating immune cells (T-cells and natural killer cells). This review investigates the potential therapeutic effects of phytostilbenes, including resveratrol, pterostilbene, piceatannol, and pinosylvin, against lymphoma. [Display omitted] •.Lymphoma is a cancer affecting the lymphatic system.•Phytostilbenes have shown diverse effects including anticancer.•Phytostilbenes can suppress the growth and proliferation of lymphoma cells via different mechanisms, described.•Phytostilbenes strengthened the immune system's ability to tbht cancer cells, described.•This review suggested the significant role of phytostilbenes as a potential ttherapeutic modality against lymphoma.