Probiotics and nutraceuticals as a new frontier in obesity prevention and management

• Published in: Diabetes research and clinical practice Vol. 141; pp. 190 - 199
• Main Authors: Kobyliak, N., Falalyeyeva, T., Boyko, N., Tsyryuk, O., Beregova, T., Ostapchenko, L.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.07.2018
• Subjects: FXR; NAFLD; LDL-C; HFD; VAT; GLP; ACAT; INF-γ; LPS; HDL-C; WPI; CFU; PPAR; BSH; SREBP1c; TGF-β; GA; MSG; IL; IR; SCFA; TC; TG; ZO; FAS
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2018.05.005

The beneficial interaction between the microbiota and humans is how bacteria contained within the gut ‘talk’ to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats. Totally, 75 rats divided into five groups were included (n = 15, in each). Rats in group I were intact. Newborn rats in groups II–V were injected with MSG. Group III (Symbiter) received 2.5 ml/kg of multiprobiotic “Symbiter” containing concentrated biomass of 14 probiotic bacteria genera. Groups IV (Symbiter-Omega) and V (Symbiter-Smectite) received a combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1–5%) or smectite gel (250 mg), respectively. In all interventional groups, significant reductions of total body and visceral adipose tissue weight as compared to MSG-obesity were observed. However, the lowest prevalence of obesity was noted for Symbiter-Omega (20% vs 33.3% as compared to other interventional groups). Moreover, supplementation of probiotics with omega-3 lead to a more pronounced decrease in HOMA-IR (2.31 ± 0.13 vs 4.02 ± 0.33, p < 0.001) and elevation of adiponectin levels (5.67 ± 0.39 vs 2.61 ± 0.27, P < 0.001), compared to the obesity group. Probiotics and nutraceuticals led to a significantly lower prevalence of obesity, reduction of insulin resistance, total and VAT weight. Our study demonstrated that supplementation of probiotics with omega-3 may have the most beneficial antiobesity properties.