Recent progress on polySarcosine as an alternative to PEGylation: Synthesis and biomedical applications

[Display omitted] Biotherapeutic PEGylation to prolong action of medications has gained popularity over the last decades. Various hydrophilic natural polymers have been developed to tackle the drawbacks of PEGylation, such as its accelerated blood clearance and non-biodegradability. Polypeptoides, s...

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Published inInternational journal of pharmaceutics Vol. 653; p. 123871
Main Authors Kabil, Mohamed Fawzi, Azzazy, Hassan Mohamed El-Said, Nasr, Maha
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 25.03.2024
Subjects
Biocompatible Materials
Biomedical applications
Peptides - chemistry
Polyethylene glycol
Polyethylene Glycols - chemistry
Polymers
Polypeptoids
Polysarcosine
Sarcosine - analogs & derivatives
Sarcosine - chemistry
Polypeptoids
Polysarcosine
Biomedical applications
Polyethylene glycol
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Summary:[Display omitted] Biotherapeutic PEGylation to prolong action of medications has gained popularity over the last decades. Various hydrophilic natural polymers have been developed to tackle the drawbacks of PEGylation, such as its accelerated blood clearance and non-biodegradability. Polypeptoides, such as polysarcosine (pSar), have been explored as hydrophilic substitutes for PEG. pSar has PEG-like physicochemical characteristics such as water solubility and no reported cytotoxicity and immunogenicity. This review discusses pSar derivatives, synthesis, characterization approaches, biomedical applications, in addition to the challenges and future perspectives of pSar based biomaterials as an alternative to PEG.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2024.123871