Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy

The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy...

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Published inThe open dentistry journal Vol. 2; no. 1; pp. 78 - 88
Main Authors Ohkura-Hada, Shuri, Kondoh, Nobuo, Hada, Akiyuki, Arai, Masaaki, Yamazaki, Yutaka, Shindoh, Masanobu, Kitagawa, Yoshimasa, Takahashi, Masayuki, Ando, Toshifumi, Sato, Yasunori, Yamamoto, Mikio
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Open 09.06.2008
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Summary:The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.
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ISSN:1874-2106
1874-2106
DOI:10.2174/1874210600802010078