Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment

• Published in: Frontiers of materials science Vol. 17; no. 2; p. 230641
• Main Authors: Li, Fangling, Han, Xiaoman, Cao, Dongdong, Yin, Junxia, Chen, Li, Li, Dongmei, Cui, Lin, Liu, Zhiyong, Guo, Xuhong
• Format: Journal Article
• Language: English
• Published: Beijing Higher Education Press 01.06.2023; Springer Nature B.V
• Subjects: Aerogels; antibacterial; Antifouling; Biocompatibility; Blood; Chemistry and Materials Science; Contact angle; Crosslinking; Emergencies; Gelatin; heat preservation; Hemorrhage; hemostasis; Hemostatics; Imines; Materials Science; Nanowires; Pectin; Polydimethylsiloxane; Polyvinyl alcohol; Research Article; Silver; Substrates; Thermal energy; wound dressing; Wound healing; antibacterial; heat preservation; wound dressing; hemostasis; antifouling
• ISSN: 2095-025X; 2095-0268
• DOI: 10.1007/s11706-023-0641-0

Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) and oxidized pectin (OP) were used for Schiff base cross-linking, and then polyvinyl alcohol (PVA) solution mixed with hemostatic caffeic acid (CA) was introduced to obtain aerogel substrate material (CB) after lyophilization. Polydimethylsiloxane (PDMS) and silver nanowires (Ag NWs) were used to construct a hydrophobic layer, an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation, antifouling, hemostasis and antibacterial properties (PDMS-Ag NW-CB). The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0, so that thermal energy loss from the body is minimized. The contact angles with water and blood are 129° and 120°, respectively, which have the effect of antifouling. This dressing can absorb blood quickly within 10 min, adhere to and gather platelets, and achieve hemostasis. It has good antibacterial and biocompatibility. Therefore, PDMS-Ag NW-CB has great potential in application to emergency treatment.