Does unilateral laparoscopic diathermy adjusted to ovarian volume increase the chances of ovulation in women with polycystic ovary syndrome?

• Published in: Human reproduction (Oxford) Vol. 28; no. 9; pp. 2417 - 2424
• Main Authors: Sunj, M., Canic, T., Baldani, D.P., Tandara, M., Jeroncic, A., Palada, I.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2013
• Subjects: Adult; Clomiphene - therapeutic use; Cohort Studies; Croatia - epidemiology; Diathermy - adverse effects; Drug Resistance; Female; Fertility Agents, Female - therapeutic use; Humans; Infertility, Female - etiology; Infertility, Female - prevention & control; Laparoscopy - adverse effects; Longitudinal Studies; Organ Size; Organ Sparing Treatments - adverse effects; Ovary - diagnostic imaging; Ovary - drug effects; Ovary - physiopathology; Ovary - surgery; Ovulation; Polycystic Ovary Syndrome - diagnostic imaging; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - physiopathology; Polycystic Ovary Syndrome - surgery; Postoperative Complications - prevention & control; Pregnancy; Pregnancy Rate; Time-to-Pregnancy; Tissue Adhesions - etiology; Tissue Adhesions - prevention & control; Ultrasonography; laparoscopic ovarian diathermy; ovary volume; polycystic ovary syndrome; ovulation; side of the ovary
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/det273

STUDY QUESTION Does unilateral volume-adjusted laparoscopic diathermy increase the chances of ovulation in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Although unilateral laparoscopic ovarian drilling (ULOD) using adjusted thermal doses was more efficient than bilateral laparoscopic ovarian drilling (BLOD) using fixed doses, the chances of ovulation were improved in patients irrespective of the technique used. WHAT IS KNOWN ALREADY The adjustment of the thermal dose to ovarian volume in BLOD increases ovulation and pregnancy rates compared with fixed-dose treatment, but BLOD causes the formation of adhesions, particularly on the left ovary, and increases the risk of damage to ovarian tissue. In contrast, ULOD with a fixed thermal dose minimizes the risk of ovarian tissue damage, and can increase the activity in both right and left ovaries, although this varies in humans and in other species. STUDY DESIGN, SIZE, DURATION This prospective, longitudinal, study, between September 2009 and January 2013, included 96 infertile women with PCOS who were unresponsive to clomiphene citrate treatment and had underwent either ULOD or BLOD. After surgery, the groups were followed up for 6 months to assess ovulatory response. PARTICIPANTS/MATERIALS, SETTING, METHODS Patients were assigned to two groups; one group underwent laparoscopic ovarian drilling of the right ovary alone, while both ovaries were treated in the second group. The ULOD group (n = 49) received thermal doses adjusted to the volume of the right ovary (60 J/cm3). The BLOD group (n = 47) received fixed doses of 600 J per ovary, regardless of its volume. The two treatment groups were matched by the number of participants, age and baseline parameters. MAIN RESULTS AND THE ROLE OF CHANCE The ovulation rate during the first menstrual cycle after LOD was significantly higher in the ULOD group than in the BLOD group [73 versus 49%; absolute risk reduction (ARR), −0.25; 95% confidence interval (CI), −0.44 to −0.03; P = 0.014]. Treatment with ULOD on the right ovary significantly increased the chances of ovulation in patients with a larger right ovary compared with those who had a smaller right ovary (100 versus 36%; ARR, −0.64; 95% CI, −0.84 to −0.37; P = 0.004). Interestingly, the chances of ovulation were also significantly higher in patients in the BLOD group who had a larger right ovary compared with those who had a smaller right ovary (88 versus 33%; ARR, −0.55; 95% CI, −0.73 to −0.28; P = 0.002). The pregnancy rate was also significantly higher in patients with a larger right ovary compared with those with a smaller right ovary, regardless of the treatment group. LIMITATIONS, REASONS FOR CAUTION The 6-month follow-up was too short to demonstrate any long-term differences in the ovulation rates. Future research should therefore extend the follow-up beyond 6 months. Another limitation is that ULOD was used to treat only the right ovary. Future studies should investigate whether ULOD treatment of the larger ovary, whether left or right, would significantly increase the ovulation rate. WIDER IMPLICATIONS OF THE FINDINGS This study represents an advance in the determination of the optimal laparoscopic treatment for women with PCOS, as it was shown that improved results can be achieved using less thermal energy in volume-adjusted ULOD. STUDY FUNDING/COMPETING INTEREST(S) The study was not funded. The authors declare no conflicting interests. TRIAL REGISTRATION NUMBER NCT01833949 (ClinicalTrials.gov.).