Acute cardiotoxicity associated with alemtuzumab infusion for multiple sclerosis
Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes im...
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| Published in | Multiple sclerosis Vol. 26; no. 6; p. 735 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.05.2020
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes improved with cessation of alemtuzumab and conservative management. The presumed cause was infusion-associated cytokine release, but the precise mechanism is unknown. |
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| AbstractList | Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes improved with cessation of alemtuzumab and conservative management. The presumed cause was infusion-associated cytokine release, but the precise mechanism is unknown. |
| Author | Leary, Siobhan M Ahrabian, Dariush Neill, Lorna Bell, Robert |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32298216$$D View this record in MEDLINE/PubMed |
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| Title | Acute cardiotoxicity associated with alemtuzumab infusion for multiple sclerosis |
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