Acute cardiotoxicity associated with alemtuzumab infusion for multiple sclerosis

Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes im...

Full description

Saved in:
Bibliographic Details
Published inMultiple sclerosis Vol. 26; no. 6; p. 735
Main Authors Ahrabian, Dariush, Neill, Lorna, Bell, Robert, Leary, Siobhan M
Format Journal Article
LanguageEnglish
Published England 01.05.2020
Subjects
infusion reaction
multiple sclerosis
Alemtuzumab
Online AccessGet more information

Cover

More Information
Summary:Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes improved with cessation of alemtuzumab and conservative management. The presumed cause was infusion-associated cytokine release, but the precise mechanism is unknown.
ISSN:1477-0970
DOI:10.1177/1352458519855725