A Study of Size, Microscopic Morphology, and Dispersion Mechanism of Structures Generated on Hydration of Proliposomes

Proliposomes were made by coating lactose monohydrate (LMH), sucrose or sorbitol particles with phosphatidylcholine. Proliposomes hydrated under static (i.e., no shaking) conditions instantly generated liposomes which deaggregated immediately using sorbitol carrier and over a period of 5 minutes usi...

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Bibliographic Details
Published inJournal of dispersion science and technology Vol. 33; no. 8; pp. 1121 - 1126
Main Authors Elhissi, Abdelbary M. A., Ahmed, Waqar, McCarthy, David, Taylor, Kevin M. G.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis Group 01.08.2012
Taylor & Francis
Taylor & Francis Ltd
Subjects
Chemistry
Colloidal state and disperse state
Dispersion
Exact sciences and technology
General and physical chemistry
liposome
Membranes
morphology
proliposome
size
Sucrose
Sorbitol
Vesicle
Hydration
Sucrose
Liposome
Dispersion
Mechanism
Particle
proliposome
Lactose
size
Formulation
Morphology
Phosphatidylcholine
Procedure
Structure
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Summary:Proliposomes were made by coating lactose monohydrate (LMH), sucrose or sorbitol particles with phosphatidylcholine. Proliposomes hydrated under static (i.e., no shaking) conditions instantly generated liposomes which deaggregated immediately using sorbitol carrier and over a period of 5 minutes using LMH or sucrose particles. Manual dispersion of sucrose-based or sorbitol-based proliposomes generated spherical vesicles, while vesicles generated from LMH-based proliposomes were rich in elongated wormlike structures. The effect of formulation on liposome size was minimal. Overall, carrier type and hydration procedure of proliposomes had a marked effect on liposome morphology while formulation had minimal effect on liposome size.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932691.2011.599233