Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma

• Published in: Neurosurgical review Vol. 29; no. 3; pp. 242 - 245
• Main Authors: Wada, Tsukasa, Kuroda, Kiyoshi, Yoshida, Yuki, Ogasawara, Kuniaki, Ogawa, Akira, Endo, Shigeatsu
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2006
• Subjects: Aged; Aged, 80 and over; Blood Cell Count; C-Reactive Protein; Disease Progression; Female; Hematoma, Subdural, Chronic - diagnostic imaging; Hematoma, Subdural, Chronic - metabolism; Hematoma, Subdural, Chronic - pathology; Humans; Interleukin-10 - metabolism; Interleukin-6 - metabolism; Interleukin-8 - metabolism; Male; Middle Aged; Recurrence; Tomography, X-Ray Computed
• ISSN: 0344-5607; 1437-2320
• DOI: 10.1007/s10143-006-0019-7

We investigated the relationship between inflammatory and anti-inflammatory cytokines in the pathogenesis of chronic subdural hematoma (CSDH) by measuring the plasma and subdural fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). The levels of IL-6, IL-8 and IL-10 were measured in the subdural fluid obtained from 34 patients with CSDH, using the enzyme-linked immunosorbent assay. The patients were classified into a high IL-10 group and a low IL-10 group according to the level of IL-10 in their subdural fluid samples. The subdural fluid levels of IL-6 and IL-8 were significantly higher in the high IL-10 group than in the low IL-10 group (P<0.05). A tendency for the patients in the low IL-10 group to show the separated or layer type of pattern on the CT scans was noted.