A single session of high-intensity interval exercise increases antioxidants defenses in the hippocampus of Wistar rats

• Published in: Physiology & behavior Vol. 211; p. 112675
• Main Authors: Melo, Camila S., Rocha-Vieira, Etel, Freitas, Daniel Almeida, Soares, Bruno A., Rocha-Gomes, Arthur, Riul, Tania Regina, Mendonça, Vanessa Amaral, Lacerda, Ana Cristina Rodrigues, Camargos, Ana Cristina Resende, Carvalho, Luciana Estefani Drumond, De Sousa, Ricardo Augusto Leoni, Leite, Hércules Ribeiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019
• Subjects: Brain tissue; High-intensity interval training; Inflammation; Physical exercise; Physical exercise; High-intensity interval training; Inflammation; Brain tissue
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2019.112675

It is known that a single session of high-intensity interval exercise (HIIE) contributes to the increase of the reactive species of oxygen, accompanied by a greater antioxidant activity. However, it is poorly understood if a single session of HIIE has similar effects on the brain tissue. This study evaluated the effects of a single HIIE on the hippocampal redox status. Sixteen males Wistar rats were allocated into HIIE (n = 8) and control (n = 8) groups. Maximum oxygen consumption (VO2max) was evaluated using a treadmill at 10° inclination in a metabolic chamber. HIIE group was submitted to a single run on the treadmill composed by 10 bouts of high-intensity exercise of 1 min each (85–100% of VO2max), at 28 m/min, 10° inclination, interspersed by 2 min of active recovery, at 10 m/min, with no inclination. Analysis of the redox status at the hippocampus were conducted 24 h after the HIIE session. It was not identified lipid peroxidation in the hippocampus of the HIIE group (Control 1.9 ± 0.31, vs HIIT 2.2 ± 0.53 nmol MDA/mg protein (p > .05). However, the activity of the superoxide dismutase (Control 2.614 ± 0.225 vs HIIT 3.718 ± 0.4589 U/mg protein), and the non-enzymatic total antioxidant capacity (Control 1584 ± 75.88 vs HIIT 1984 ± 137.7 nM FeSO4/mg protein) were enhanced (p < .05) after the exercise session. These results indicate that the antioxidant mechanisms are enhanced even after a single session of HIIE. A single session of HIIE does not induce lipid peroxidation and improves the antioxidant defenses in Wistar rats' hippocampus. •Antioxidant capacity is enhanced after a single session of high-intensity interval exercise (HIIE) on rats' hippocampus.•A single session of HIIE does not induce lipid peroxidation on rats' hippocampus.•A single session of HIIE improves enzymatic and non-enzymatic total antioxidant capacity in Wistar rats' hippocampus.