Rapid microneedle fabrication by heating and photolithography

• Published in: International journal of pharmaceutics Vol. 575; p. 118992
• Main Authors: Kathuria, Himanshu, Kang, Kristacia, Cai, Junyu, Kang, Lifeng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.02.2020
• Subjects: Dissolving microneedles; Fabrication; Microneedle; Photolithography; PVP; Thermal; Fabrication; Dissolving microneedles; PVP; Photolithography; Microneedle; Thermal
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2019.118992

Many fabrication methods for microneedle (MN) involve harsh conditions and long drying time. This study aims to fabricate a dissolving MN patch in a simple and efficient manner under mild conditions, using a combination of thermal and photo polymerisation. The MN patch was fabricated by pre-polymerisation of vinylpyrrolidone solution with heating followed by photolithography. The heating temperature and time of pre-polymer solution curing were optimized based on viscosity measurement. The MN properties including shape, size, skin penetration, dissolution, moisture absorption were determined. The fabricated MNs were sharp and consistent. The heated N-vinylpyrrolidone solution required less UV exposure time, thus reducing the total fabrication time. The percentage of MN penetration in human cadaver skin was more than 33.9%. The MN was dissolved within 1–2 min in water, or 40 min in saturated water vapor.