Predictor of Surgical Failure Following Transvaginal Mesh Repair Using Minimally Invasive Prolapse System Device (MIPS)

• Published in: Journal of clinical medicine Vol. 13; no. 18; p. 5352
• Main Authors: Yang, Yao-Yu, Loo, Zi-Xi, Lin, Kun-Ling, Long, Cheng-Yu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.09.2024; MDPI
• Subjects: Care and treatment; Equipment and supplies; Failure; FDA approval; Hysterectomy; Medical research; Medicine, Experimental; Methods; Minimally invasive surgery; Patient outcomes; Patients; Pelvic organ prolapse; Physiological aspects; Prolapse; Questionnaires; Surgeons; Surgery; Surgical outcomes; Surgical techniques; Surgical technology; Treatment outcome; Uterus; Vagina; Taiwan; United States > US; recurrence; uterine prolapse; surgical failure; transvaginal mesh repair; pelvic organ prolapse
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm13185352

The Minimally Invasive Prolapse System (MIPS) device, a novel single-incision transvaginal mesh, represents recent advancements in mesh technology, providing lightweight, biocompatible support for pelvic organ prolapse while reducing erosion, allowing for customization and improving surgical outcomes. This study aimed to identify factors associated with pelvic organ prolapse (POP) recurrence after transvaginal mesh (TVM) repair using the Minimally Invasive Prolapse System device. Two hundred and eighteen women with symptomatic stage II to IV POP underwent TVM. Preoperative and postoperative assessments included urinalyses and pelvic examinations using the POP quantification (POP-Q) staging system. During a follow-up period of 12-46 months, 7 of 218 (3.2%) women experienced POP recurrence. Univariate analysis was conducted to identify predictors of surgical failure, revealing no significant differences in body mass index, POP stage, or preoperative urinary symptoms between the recurrence and success groups ( > 0.05). However, functional urethral length <20 mm based on urodynamics ( = 0.011), ICI-Q scores ≥7 ( = 0.012), and the first 60 surgical cases ( = 0.018) were significant predictors of surgical failure. Multivariate logistic regression confirmed these findings. Functional urethral length <20 mm, ICI-Q scores ≥7, and limited surgical experience were significant predictors of TVM failure using the Minimally Invasive Prolapse System kit. POP recurrence after mesh repair is less likely beyond the learning curve.