Penicacids E–G, three new mycophenolic acid derivatives from the marine-derived fungus Penicillium parvum HDN17-478

• Published in: Chinese journal of natural medicines Vol. 18; no. 11; pp. 850 - 854
• Main Authors: CHEN, Xiao-Hui, ZHOU, Guo-Liang, SUN, Chun-Xiao, ZHANG, Xiao-min, ZHANG, Guo-Jian, ZHU, Tian-Jiao, LI, Jing, CHE, Qian, LI, De-Hai
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.11.2020
• Subjects: Cytotoxicity; Marine-derived fungus; Mycophenolic acid derivatives; Penicillium parvum; Cytotoxicity; Mycophenolic acid derivatives; Penicillium parvum; Marine-derived fungus
• ISSN: 1875-5364; 1875-5364
• DOI: 10.1016/S1875-5364(20)60027-9

Three new mycophenolic acid derivatives, penicacids E–G (1–3), together with three known analogues, mycophenolic acid (4), 4′-hydroxy-mycophenolic acid (5) and mycophenolic methyl ester (6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South China Sea marine sediment sample. The structures of compounds 1–3 were elucidated by HRMS, NMR, and Mosher's method. Among them, compounds 1 and 2 were the first examples of mycophenolic acid analogs with a double bond at C-3′/C-4′ position. The cytotoxicity of 1–6 was evaluated against the HCT-116, BEL-7402, MGC-803, SH-SY5Y, HO-8910 and HL-60 cell lines, and compounds 4 and 6 showed potent cytotoxicity with IC50 values ranging from 1.69 to 12.98 μmol·L−1.