First Report: Colistin Resistance Gene mcr-3.1 in Salmonella enterica Serotype Choleraesuis Isolated from Human Blood Sample from Thailand

• Published in: Microbial drug resistance (Larchmont, N.Y.) Vol. 28; no. 1; p. 102
• Main Authors: Oransathid, Wilawan, Sukhchat, Prawet, Margulieux, Katie, Wongpatcharamongkol, Nantanat, Kormanee, Rosarin, Pimsawat, Theerasak, Preston, Lan, Corey, Brendan, Vesely, Brian, Waters, Norman, Demons, Samandra, Lurchachaiwong, Woradee
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Anti-Bacterial Agents - pharmacology; Colistin - pharmacology; Drug Resistance, Multiple, Bacterial - genetics; Genes, Bacterial; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Phenotype; Salmonella - drug effects; Salmonella - genetics; Serogroup; Thailand; Thailand; colistin resistance; Salmonella Choleraesuis; human blood sample; mcr-3.1
• ISSN: 1931-8448
• DOI: 10.1089/mdr.2020.0553

This study describes the first finding of serotype Choleraesuis ( Choleraesuis) isolate harboring mobile colistin resistance obtained from human blood sample. The clinical relevant blood sample was collected during October 2018. The phenotypic identification and antimicrobial susceptibility testing (AST) were studied by using automate microbiology platform (Phoenix M50, BD), and in-depth characterization by whole genome sequencing. The phenotypic identification was reported Choleraesuis. AST result demonstrated that this isolate had high minimum inhibitory concentrations (MICs) against colistin, fluoroquinolone, and cephalosporin III and IV, which are first-line antibiotic treatment choices for Gram-negative bacterial pathogen infections. This Choleraesuis is harboring and presented a diversity carbapenemase including and Regarding the multilocus sequence typing result, this Salmonella presented ST139 that related to the Choleraesuis variant . Swine is not the host specific for the Choleraesuis since it also causes enteric and other diseases in human. Hence, the presence of the mobile plasmid colistin resistant gene in human sample is resulting to the public health concerns due to the fact that it is enable to transmit to other hosts and distribute into an environment.