Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degrad...

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Published inFrontiers of chemical science and engineering Vol. 15; no. 2; pp. 221 - 237
Main Authors Feng, Simin, Zhang, Xiaoli, Shi, Dunyun, Wang, Zheng
Format Journal Article
LanguageEnglish
Published Beijing Higher Education Press 01.04.2021
Springer Nature B.V
Subjects
Aluminosilicates
Aluminum silicates
Chemistry
Chemistry and Materials Science
Industrial Chemistry/Chemical Engineering
Metal-organic frameworks
Nanotechnology
Porous materials
Review Article
Synthesis
Zeolites
Zinc
zeolitic imidazolate framework-8 (ZIF-8)
drug delivery
synthesis methods
applications
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Summary:Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.
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ISSN:2095-0179
2095-0187
DOI:10.1007/s11705-020-1927-8