Attitudinal and social predictors of adherence to oral endocrine therapy: A psychometrically-informed model

• Published in: Journal of health psychology Vol. 27; no. 4; pp. 913 - 922
• Main Authors: Rivers, Alannah Shelby, Sanford, Keith, Elkins, Gary, Carpenter, Janet S, Rand, Kevin L, Bartlett Ellis, Rebecca J
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.03.2022; SAGE PUBLICATIONS, INC
• Subjects: Adherence; Attitudes; Breast cancer; Breast Neoplasms - drug therapy; Chemotherapy, Adjuvant; Confusion; Endocrine therapy; Female; Hormone replacement therapy; Humans; Interpersonal relations; Medication Adherence; Quantitative psychology; Self Report; Social factors; Women; social support; breast cancer; adherence; physician-patient relationships; attitude
• ISSN: 1359-1053; 1461-7277
• DOI: 10.1177/1359105320982039

There is a need for a psychometrically-informed model identifying attitudinal and social factors explaining adherence to oral endocrine therapy (OET) for women with hormone receptor positive breast cancer. This study tested a model with variables selected by stringent psychometric criteria, including attitudes about benefit and burden, patient-practitioner alliance and confusion, and positive and negative interpersonal interactions. Self-report scales were completed by 150 current or past OET users. Fourteen correlations and six mediated pathways implied by the model were tested. All hypothesized associations were significant. This preliminary study suggests the model is a valuable framework for OET adherence research and intervention.