Baseline haemoglobin and thromboelastometry are predictive of red blood cell requirements and one-year mortality in liver transplantation

• Published in: Transfusion and apheresis science Vol. 60; no. 6; p. 103259
• Main Authors: Viguera, Laura, Blasi, Annabel, Reverter, Enric, Arjona, Begoña, Caballero, Marta, Chocron, Ivette, García-López, José Antonio, Gutierrez, Rosa, Martin, Maria Jesús, Pérez-Peña, Jose, Pitera, Javier, Zarragoikoetxea, Iratxe, Sabaté, Antoni
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2021
• Subjects: Adult; Aged; Erythrocyte Transfusion - methods; Female; Haemoglobin; Hemoglobins - analysis; Hemoglobins - metabolism; Humans; Liver transplantation; Liver Transplantation - mortality; Male; Middle Aged; Mortality; Red blood cell transfusion; Thrombelastography - methods; Thromboelastometry; Young Adult; Red blood cell transfusion; Thromboelastometry; Haemoglobin; Mortality; Liver transplantation
• ISSN: 1473-0502; 1878-1683
• DOI: 10.1016/j.transci.2021.103259

To determine the predictive capacity of baseline haemoglobin and maxim clot firmness (MCF) EXTEM thromboelastometry for intraoperative red blood cell (RBC) requirements and its influence on mortality. 591 adult liver transplant (LT) recipients from ten Spanish centres were reviewed. The main outcomes were the percentage of patients who received RBC and massive transfusion (≥ 6 RBC units), RBC units transfused, and mortality. 76 % received a donor after brain death graft and 24 % a controlled donor after circulatory death graft. Median (interquartile ranges) RBC transfusion was 2 (0–4) units, and 63 % of patients were transfused. Comparing transfused and non-transfused patients, mean (standard deviation) for baseline haemoglobin was 10.4 (2.1) vs. 13.0 (1.9) g/dl (p = 0.001), EXTEM MCF was 51(11) vs. 55(9) mm (p = 0.001). Haemoglobin and EXTEM MCF were inversely associated with the need of transfusion odds ratio (OR) of 0.558 (95 % CI 0.497–0.627, p < 0.001) and OR 0.966 (95 % CI0.945–0.987, p = 0.002), respectively. Pre-operative baseline haemoglobin ≤ 10 g/dL predicted RBC transfusion, sensitivity of 93 % and specificity of 47 %. Massive transfusion (MT) was received by 19 % of patients. Haemoglobin ≤10 g/dL predicted MT with sensitivity 73 % and specificity of 52 %. One-year patient and graft survival were significantly lower in patients who required MT (78 % and 76 %, respectively) vs. those who did not (94 % and 93 %, respectively). whereas EXTEM MCF is less dreterminant predicting RBC requirements, efforts are required to improve preoperative haemoglobin up to 10 g/dl in patients awaiting LT.