Recent developments of aptasensors expedient for point-of-care (POC) diagnostics

• Published in: Talanta (Oxford) Vol. 199; pp. 556 - 566
• Main Authors: Citartan, Marimuthu, Tang, Thean-Hock
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2019
• Subjects: Aptamer; Aptamers, Nucleotide - chemical synthesis; Aptamers, Nucleotide - chemistry; Biosensing Techniques; Colorimetry; Electrochemical Techniques; Fluorescence; Humans; Point-of-care diagnostics; Point-of-Care Systems; Portable sensor; Surface Plasmon Resonance; Point-of-care diagnostics; Aptamer; Portable sensor
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2019.02.066

Aptamers are nucleic acid-based molecular recognition elements that are specific and have high binding affinity against their respective targets. On account of their target recognition capacity, aptamers are widely utilized in a number of applications including diagnostics. This review aims to highlight the recent developments of aptasensors expedient for point-of-care (POC) diagnostics. Significant focus is given on the primary assay formats of aptamers such as fluorescence, electrochemical, surface plasmon resonance (SPR) and colorimetric assays. A potpourri of platforms such as paper-based device, lateral flow assay, portable electrodes, portable SPR and smart phones expedient for point-of-care (POC) diagnostics are discussed. Emphasis is also given on the technicalities and assay configurations associated with the sensors. [Display omitted] •This review aims to highlight the recent developments of aptasensors expedient for point-of-care (POC) diagnostics.•· Platforms including paper-based device, lateral flow assay and other platforms amenable for POC diagnostics are gleaned.•Focus is given on the technicalities and assay configurations associated with the sensors.