Concomitant use of levofloxacin and fluconazole leading to possible torsades de pointes

Prolongation of the corrected QT interval can lead to the deadly arrhythmia torsades de pointes. There are many risk factors for corrected QT prolongation, one being medication. The goal of this case report is to add to the limited literature surrounding the possibility of torsades de pointes when l...

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Bibliographic Details
Published inJournal of oncology pharmacy practice Vol. 25; no. 8; p. 2004
Main Authors Tilton, Jessica J, Sadr, Rozhan, Groo, Vicki L
Format Journal Article
LanguageEnglish
Published England 01.12.2019
Subjects
Adult
Electrocardiography
Female
Fluconazole - adverse effects
Fluconazole - therapeutic use
Humans
Levofloxacin - administration & dosage
Levofloxacin - adverse effects
Long QT Syndrome - chemically induced
Risk Factors
Torsades de Pointes - chemically induced
fluconazole
corrected QT
levofloxacin
Torsades de pointes
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Summary:Prolongation of the corrected QT interval can lead to the deadly arrhythmia torsades de pointes. There are many risk factors for corrected QT prolongation, one being medication. The goal of this case report is to add to the limited literature surrounding the possibility of torsades de pointes when levofloxacin and fluconazole are used concomitantly. Additionally, provide guidance for patient factors that need to be assessed when prescribing the two drugs.
ISSN:1477-092X
DOI:10.1177/1078155218815743