Validation of oxygen consumption measurements during artificial ventilation

We describe a system for the absolute calibration of indirect calorimeters, under the conditions of artificial ventilation and increased inspired O2 concentration, in which butane, at a measured flow rate, is burned downstream of an artificial lung. One milliliter of butane requires 6.4 ml O2 for it...

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Bibliographic Details
Published inJournal of applied physiology (1985) Vol. 67; no. 5; p. 2129
Main Authors Nunn, J F, Makita, K, Royston, B
Format Journal Article
LanguageEnglish
Published United States 01.11.1989
Subjects
Butanes
Calorimetry - methods
Calorimetry, Indirect - methods
Humans
Lung - metabolism
Models, Anatomic
Oxygen Consumption
Reproducibility of Results
Respiration, Artificial
Spirometry
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Summary:We describe a system for the absolute calibration of indirect calorimeters, under the conditions of artificial ventilation and increased inspired O2 concentration, in which butane, at a measured flow rate, is burned downstream of an artificial lung. One milliliter of butane requires 6.4 ml O2 for its combustion, and the respiratory quotient is 0.615. With the closed-circuit O2-replenishment method there was no significant systematic error in the measurement of either O2 consumption or CO2 output and a random error with a SD of 8.3 ml/min for O2 consumption and 6.3 ml/min for CO2 output. There were no significant differences in the errors with inspired O2 concentrations between 23.8 and 59.5% and O2 consumptions between 89 and 366 ml/min.
ISSN:8750-7587
DOI:10.1152/jappl.1989.67.5.2129