Modeling transport through synthetic nanopores

Synthetic nanopores have arisen as a convenient means of characterizing single molecules, with DNA being one of the most popular subjects. By applying an electric field, ions and charged biomolecules like DNA can be compelled to interact with, or translocate through, nanopores in thin membranes. The...

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Bibliographic Details
Published inIEEE nanotechnology magazine Vol. 3; no. 1; pp. 20 - 28
Main Authors Aksimentiev, A., Brunner, R., Cruz-Chu, E., Comer, J., Schulten, K.
Format Magazine Article
LanguageEnglish
Published United States IEEE 01.03.2009
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Biological materials
Biomembranes
Charging
Computational modeling
Deoxyribonucleic acid
DNA
Geometry
Landmarks
Molecular biophysics
Nanocomposites
Nanomaterials
Nanoporous materials
Nanostructure
Nanotechnology
Proteins
Protocols
Silicon
Transport
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Summary:Synthetic nanopores have arisen as a convenient means of characterizing single molecules, with DNA being one of the most popular subjects. By applying an electric field, ions and charged biomolecules like DNA can be compelled to interact with, or translocate through, nanopores in thin membranes. The use of the nanopore method for characterizing nucleic acids gained initial momentum in 1996 with a landmark paper by Kasianowicz et al.
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ISSN:1932-4510
1942-7808
DOI:10.1109/MNANO.2008.931112