Chitosan/fucoidan multilayer coating of gold nanorods as highly efficient near-infrared photothermal agents for cancer therapy

[Display omitted] •GNRs coated with the dual polymer is attractive for cancer therapy.•This is the first report on CS/F-GNRs as novel agents for photothermal therapy.•CS/F-GNRs under laser irradiation could completely ablate tumor in mice.•CS/F-GNRs as safe and highly efficient NIR photothermal agen...

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Published inCarbohydrate polymers Vol. 211; pp. 360 - 369
Main Authors Manivasagan, Panchanathan, Hoang, Giang, Santha Moorthy, Madhappan, Mondal, Sudip, Minh Doan, Vu Hoang, Kim, Hyehyun, Vy Phan, Thi Tuong, Nguyen, Thanh Phuoc, Oh, Junghwan
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2019
Subjects
Chitosan
Fucoidan
Gold nanorods
Multilayer
Photothermal therapy
Photothermal therapy
Chitosan
Fucoidan
Gold nanorods
Multilayer
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Summary:[Display omitted] •GNRs coated with the dual polymer is attractive for cancer therapy.•This is the first report on CS/F-GNRs as novel agents for photothermal therapy.•CS/F-GNRs under laser irradiation could completely ablate tumor in mice.•CS/F-GNRs as safe and highly efficient NIR photothermal agents for cancer therapy. Photothermal therapy (PTT) using chitosan/fucoidan multilayer coating of gold nanorods (CS/F-GNRs) has emerged as an alternative strategy for cancer therapy. In this study, biocompatible CS/F-GNRs were synthesized as a new generation of photothermal therapeutic agents for in vivo cancer treatments owing to their good biocompatibility, photostability, and strong absorption in the near-infrared (NIR) region. The CS/F-GNRs showed a good size distribution (51.87 ± 3.03 nm), and the temperature variation of the CS/F-GNRs increased by 54.4 °C after laser irradiation (1.0 W/cm2) for 5 min. The in vitro photothermal efficiency of CS/F-GNRs indicated that significantly more cancer cells were killed under laser irradiation at 1.0 W/cm2 for 5 min. On the 20th day of treatment, the MDA-MB-231 tumor cells in mice treated with CS/F-GNRs under laser irradiation had almost completely disappeared. Therefore, the biocompatible CS/F-GNRs have shown great promise as safe and highly efficient near-infrared photothermal agents for future cancer therapy.
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ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2019.01.010