Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

• Published in: Journal of cutaneous medicine and surgery Vol. 20; no. 3; p. 207
• Main Authors: Maleki, Masoud, Nahidi, Yalda, Azizahari, Sahar, Meibodi, Naser Tayyebi, Hadianfar, Ali
• Format: Journal Article
• Language: English
• Published: United States 01.05.2016
• Subjects: Adult; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Iran; Male; Middle Aged; Psoriasis - blood; Psoriasis - complications; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; psoriasis; Psoriasis Area and Severity Index (PASI); serum vitamin D
• ISSN: 1615-7109
• DOI: 10.1177/1203475415622207

Vitamin D has been shown to have immunomodulatory effects, and previous studies have proposed a role of vitamin D deficiency in multiple autoimmune diseases, including psoriasis. The aim of this study was to investigate serum vitamin D levels in psoriatic patients and compare them with levels in controls. This study was carried out in 50 psoriasis patients. Serum vitamin D was measured by enzyme-linked immunosorbent assay. The mean serum vitamin D levels in psoriatic patients and controls were 14.92 ± 6.31 and 12.52 ± 4.54 ng/mL, respectively. The difference was not statistically significant (P = .06). The prevalence of vitamin D deficiency (<20 ng/mL) was 84.0% in psoriatic patients and 93.0% in controls (P = .21). Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.