Compartmentation of gluconeogenesis in the fasted eel ( Anguilla anguilla)

• Published in: Comparative biochemistry and physiology. B, Comparative biochemistry Vol. 92; no. 4; pp. 697 - 703
• Main Authors: Hansen, Heinz J.M., Abraham, S.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1989; Elsevier Science
• Subjects: Anguilla anguilla; Biological and medical sciences; Brackish; Carbohydrates; Freshwater; Fundamental and applied biological sciences. Psychology; Marine; Metabolisms and neurohumoral controls; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrata; Anguilla anguilla; Digestive system; Enzyme; Liver; Pisces; Carbohydrate; Metabolism; Phosphoenolpyruvate carboxykinase (ATP); Nutritional status; Feeding; Gluconeogenesis
• ISSN: 0305-0491
• DOI: 10.1016/0305-0491(89)90252-6

1. 1. In the fed state, the same relative incorporation of injected 14C-labelled alanine, serine, aspartate and glutamate into glyceride-glycerol in eel liver in vivo points to the enzyme phosphoenolpyruvate carboxykinase as rate limiting in gluconeognesis. 2. 2. Equivalent experiments in the fasted state show an enhancement of the incorporation of 14C-activity into glyceride-glycerol, twice as high from either alanine, lactate or pyruvate, and seven times as high from serine, as that from either aspartate, glutamate, acetate or propionate. 3. 3. This difference between the incorporation of specific precursors depending on nutrition state is interpreted as a hormone-induced compartmentation of gluconeogenesis in favour of an effective protein utilization in the fasted eel.