Expression pattern of adipocyte fatty acid-binding protein gene in different tissues and its regulation of genes related to adipocyte differentiation in duck

ABSTRACT Abundance of duck adipocyte fatty acid-binding protein (A-FABP) mRNA was detected in this study by quantitative real-time PCR. The results showed that duck A-FABP gene was expressed in muscular tissues and many organs, except pancreas, lung, and kidney, and highly expressed in adipose tissu...

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Published inPoultry science Vol. 91; no. 9; pp. 2270 - 2274
Main Authors He, J., Tian, Y., Li, J. J., Shen, J. D., Tao, Z. R., Fu, Y., Niu, D., Lu, L. Z.
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford University Press 01.09.2012
Subjects
Adipocytes - cytology
Animals
Cell Differentiation
Cell Survival
Ducks - physiology
Fatty Acid-Binding Proteins - genetics
Fatty Acid-Binding Proteins - metabolism
Female
Gene Expression
Male
Oleic Acid
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
adipocyte fatty acid-binding protein
small interfering RNA
regulation
duck
gene expression
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Summary:ABSTRACT Abundance of duck adipocyte fatty acid-binding protein (A-FABP) mRNA was detected in this study by quantitative real-time PCR. The results showed that duck A-FABP gene was expressed in muscular tissues and many organs, except pancreas, lung, and kidney, and highly expressed in adipose tissues, especially in sebum. The expression of A-FABP and adipocyte differentiation-related genes was upregulated by oleic acid, and the A-FABP knockdown suppressed the oleic acid-stimulated expression of these genes in the cultured duck adipocytes, indicating A-FABP might play an important role in duck adipocyte differentiation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.2012-02149