pH-responsive prodrug nanoparticles based on xylan-curcumin conjugate for the efficient delivery of curcumin in cancer therapy
•pH-responsive xyl-cur prodrug NPs were prepared by dialysis membrane method.•Xyl-cur prodrug NPs showed pH-responsive drug released behavior.•Xyl-cur prodrug NPs are biocompatible and safe for intravenous administration.•Xyl-cur prodrug NPs demonstrated higher cytotoxic activity than free curcumin....
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Published in | Carbohydrate polymers Vol. 188; pp. 252 - 259 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
15.05.2018
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Subjects | |
Online Access | Get full text |
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Summary: | •pH-responsive xyl-cur prodrug NPs were prepared by dialysis membrane method.•Xyl-cur prodrug NPs showed pH-responsive drug released behavior.•Xyl-cur prodrug NPs are biocompatible and safe for intravenous administration.•Xyl-cur prodrug NPs demonstrated higher cytotoxic activity than free curcumin.
In the present study, novel pH-responsive prodrug nanoparticles based on xylan-curcumin (xyl-cur) conjugate were developed to enhance the therapeutic efficacy of curcumin in cancer therapy. The synthesis of xyl-cur conjugate (prodrug) was confirmed by FT-IR, 1H NMR, UV–vis and fluorescence spectroscopy. The xyl-cur prodrug was subsequently self-assembled in to nanoparticles (xyl-cur prodrug NPs) in an aqueous medium with the average particle size 253 nm and the zeta potential of −18.76 mV. The xyl-cur prodrug NPs were highly pH-sensitive in nature and most of the drug was released at lower pH. The interaction of the xyl-cur prodrug NPs with blood components was tested by hemolysis study. The cytotoxic activity of the xyl-cur prodrug NPs against human colon cancer cells (HT-29, HCT-15) demonstrated that the prodrug NPs exhibits greater cytotoxic effect than curcumin. Therefore, these results reveal that xyl-cur prodrug NPs could be a promising candidate for improving the intracellular delivery of curcumin in cancer therapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2018.02.006 |