Lipid- and polymer-based plexes as therapeutic carriers for bioactive molecules

• Published in: International journal of pharmaceutics Vol. 558; pp. 250 - 260
• Main Authors: Shende, Pravin, Ture, Narayan, Gaud, R.S., Trotta, F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.03.2019
• Subjects: Lipid; Lipopolyplexes; Nanoparticulate drug-delivery systems; Polymer; DOPE; DMRI; AT2- R; IL; VEGF; Polymer; BGSC; PAMAM; PAGA; Lipid; PEAA; PLL; Lipopolyplexes; GDNF; Nanoparticulate drug-delivery systems; DC-chol; PEI; pHis; DOGS; DODAC; DODAB; DOPC; DOTMA; DDAB
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2018.12.085

[Display omitted] Recently, promising strategies of plexes include the complexation of nucleic acids with lipids (lipoplexes) and different kinds of polymers (polyplexes) for delivery of actives and genetic material in abnormal conditions like cancer, cystic fibrosis and genetic disorders. The present review article focuses on the comparative aspects of lipoplexes and polyplexes associated with molecular structure, cellular transportation and formulation aspects. The major advantages of lipoplexes and polyplexes over conventional liposomes involve non-immunogenic viral gene transfer, facile manufacturing and preservation of genetic material encapsulated within the nanocarriers. Lipoplexes and polyplexes enhance the transfection of DNA into the cell by stepwise electrostatic cationic-anionic interaction with DNA backbones. The ease and cost-effective formation of complexes extend their applications in the treatment of cancer and genetic disorders. Lipoplexes and polyplexes necessitate intensive research in the fields of quality, toxicity and methods of preparation for commercialization.