Screening of pesticides in serum, urine and cerebrospinal fluid collected from an urban population in China

• Published in: Journal of hazardous materials Vol. 449; p. 131002
• Main Authors: Zhao, Ke-Xin, Zhang, Ming-Yan, Yang, Dan, Zhu, Rong-Shu, Zhang, Zi-Feng, Hu, Ying-Hua, Kannan, Kurunthachalam
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.05.2023
• Subjects: Estimated daily intake; Exposure source analysis; Gas Chromatography-Mass Spectrometry - methods; Humans; OCPs; Pesticides - analysis; Risk assessment; Tandem Mass Spectrometry; Triazole fungicides; Urban Population; Exposure source analysis; OCPs; Triazole fungicides; Risk assessment; Estimated daily intake
• ISSN: 0304-3894; 1873-3336
• DOI: 10.1016/j.jhazmat.2023.131002

Human exposure to pesticides is a topic of public health concern for decades. Pesticide exposures have been assessed through the analysis of urine or blood matrices, but little is known on the accumulation of these chemicals in cerebrospinal fluid (CSF). CSF plays an important role in maintaining physical and chemical balance of the brain and central nervous system and any perturbation can have adverse effects on health. In this study, we investigated the occurrence of 222 pesticides in CSF from 91 individuals using gas chromatography-tandem mass spectrometry (GC-MS/MS). Measured pesticide concentrations in CSF were compared with those in 100 serum and urine specimens from individuals living in the same urban location. Twenty pesticides were found in CSF, serum and urine, at levels above the limit of detection. Three most frequently detected pesticides in CSF were biphenyl (100%), diphenylamine (75%), and hexachlorobenzene (63%). Median concentrations of biphenyl in CSF, serum and urine were 1.11, 10.6, and 1.10 ng/mL, respectively. Six triazole fungicides were found only in CSF, but not in other matrices. To our knowledge, this is the first study to report pesticide concentrations in CSF in a general urban population. [Display omitted] •Pesticide exposure levels in the cerebrospinal fluid of urban populations were tested.•Triazole fungicides were found in cerebrospinal fluid for the first time.•Pesticides in human are mainly from environmental exposure and food chain enrichment.•The pesticides with the highest risk are hexachlorobenzene, biphenyls and p,p′-DDE.