Is β-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?

β-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of β-glucuronidase was surprisingly observed, even within normal range. These findings do not...

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Bibliographic Details
Published inHuman & experimental toxicology Vol. 27; no. 5; pp. 431 - 433
Main Authors Sabbe, MB, Desruelles, D, Lissens, W
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.05.2008
Arnold
Subjects
Acetylcholinesterase - blood
Atropine - therapeutic use
Biological and medical sciences
Biomarkers - blood
Chemical and industrial products toxicology. Toxic occupational diseases
Cholinesterase Inhibitors - poisoning
Drug Therapy, Combination
Fluid Therapy
Glucuronidase - blood
Humans
Male
Medical sciences
Middle Aged
Obidoxime Chloride - therapeutic use
Parathion - poisoning
Poisoning - blood
Poisoning - drug therapy
Poisoning - enzymology
Propofol - therapeutic use
Suicide, Attempted
Toxicology
Various organic compounds
Vasoconstrictor Agents - therapeutic use
biomarker
β-glucuronidase
organophosphorus poisoning
Human
β-Glucuronidase
Enzyme
Acute
Biological marker
Blood plasma
Glycosylases
Case study
Glycosidases
Hydrolases
Poisoning
Organophosphorus compounds
Diagnosis
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Summary:β-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of β-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that β-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327108094614