Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

• Published in: Journal of food biochemistry Vol. 45; no. 3; pp. e13238 - n/a
• Main Authors: Akinmoladun, Afolabi C., Adegbamigbe, Adaugo Damilola, Okafor, Nkechi Ruth, Josiah, Sunday Solomon, Olaleye, M. Tolulope
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021
• Subjects: antilipemic; hyperlipidemia; multiherbal tea; multi‐organ protection; oxidative stress; antilipemic; hyperlipidemia; multiherbal tea; multi-organ protection; oxidative stress
• ISSN: 0145-8884; 1745-4514
• DOI: 10.1111/jfbc.13238

This study investigated the safety and therapeutic effect of a multiherbal tea (MHT) on Triton X‐1339‐induced hyperlipidemia and associated biochemical and tissue dysfunctions. An infusion of the MHT was assessed for phytoconstituents, proximate and mineral composition, and antioxidant activity. Wistar rats administered 200 mg/kg Triton X‐1399 were post‐treated with MHT for 14 days followed by biochemical estimations in serum, heart, liver, and kidney of animals. Hematological and histopathological evaluations of the blood, and liver, respectively, were also performed. Different phytochemicals were detected in MHT, toxic metals were absent and antioxidant activity was appreciable. Disturbances in glucose level and redox homeostasis, alterations in liver, kidney, and heart function markers, and imbalances in hematological parameters precipitated by triton toxicity were mitigated by posttreatment with MHT. Multiherbal tea also ameliorated triton‐induced hepatic histoarchitectural abnormalities. These results suggest that MHT is apparently an effective antilipemic tea with minimal or no side effects. Practical applications Hyperlipidemia is one of the core risk factors for arteriosclerosis and a major contributor to other adverse health conditions. The prevalence of hyperlipidemia has increased drastically in the last few decades. Plant and plant products have been extensively used in the management of dyslipidemia and many plant‐based antilipemic products with poorly defined toxicity and pharmacological profiles abound in the market. The results of this study demonstrated the protective effects of a MHT against triton‐induced hyperlipidemia, atherogenic tendency, and dysfunction of key organs in rats and lent credence to its therapeutic relevance in the management of hyperlipidemia and related diseases. A multiherbal tea was evaluated for protective property in Triton‐induced hyperlipidemia in rats. The tea afforded significant protection against hyperlipidemia and the associated biochemical and organ dysfunctions precipitated by triton administration.