Maternal cardiovascular function and risk of intrapartum fetal compromise in women undergoing induction of labor: pilot study

• Published in: Ultrasound in obstetrics & gynecology Vol. 56; no. 2; pp. 233 - 239
• Main Authors: Kalafat, E., Barratt, I., Nawaz, A., Thilaganathan, B., Khalil, A.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2020; Wiley Subscription Services, Inc
• Subjects: Accuracy; adverse outcome; Cardiac output; cardiovascular; Cardiovascular diseases; Cardiovascular system; Cesarean section; Childbirth & labor; fetal compromise; fetal distress; Fetuses; forceps; Health risks; Heart; Hemodynamics; Induced labor; Labor; Markers; Model accuracy; Obstetrics; Placenta; prediction; Regression analysis; Risk; Risk assessment; Stroke; Stroke volume; systemic vascular resistance; Ultrasonic imaging; vacuum; Womens health
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.21918

ABSTRACT Objective Identification of the fetus at risk of intrapartum compromise has many benefits. Impaired maternal cardiovascular function is associated with placental hypoperfusion predisposing to intrapartum fetal distress. The aim of this study was to assess the predictive accuracy of maternal hemodynamics for the risk of operative delivery due to presumed fetal compromise in women undergoing induction of labor (IOL). Methods In this prospective cohort study, patients were recruited between November 2018 and January 2019. Women undergoing IOL were invited to participate in the study. A non‐invasive ultrasonic cardiac output monitor (USCOM‐1A®) was used for cardiovascular assessment. The study outcome was operative delivery due to presumed fetal compromise, which included Cesarean or instrumental delivery for abnormal fetal heart monitoring. Regression analysis was used to test the association between cardiovascular markers, as well as the maternal characteristics, and the risk of operative delivery due to presumed fetal compromise. Receiver‐operating‐characteristics‐curve analysis was used to assess the predictive accuracy of the cardiovascular markers for the risk of operative delivery for presumed fetal compromise. Results A total of 99 women were recruited, however four women were later excluded from the analysis due to semi‐elective Cesarean section (n = 2) and failed IOL (n = 2). The rate of operative delivery due to presumed fetal compromise was 28.4% (27/95). Women who delivered without suspected fetal compromise (controls) were more likely to be parous, compared to those who had operative delivery due to fetal compromise (52.9% vs 18.5%; P = 0.002). Women who underwent operative delivery due to presumed fetal compromise had a significantly lower cardiac index (median, 2.50 vs 2.60 L/min/m2; P = 0.039) and a higher systemic vascular resistance (SVR) (median, 1480 vs 1325 dynes × s/cm5, P = 0.044) compared to controls. The baseline model (being parous only) showed poor predictive accuracy, with an area under the curve of 0.67 (95% CI, 0.58–0.77). The addition of stroke volume index (SVI) < 36 mL/m2, SVR > 7.2 logs or SVR index (SVRI) > 7.7 logs improved significantly the predictive accuracy of the baseline model (P = 0.012, P = 0.026 and P = 0.012, respectively). Conclusion In this pilot study, we demonstrated that prelabor maternal cardiovascular assessment in women undergoing IOL could be useful for assessing the risk of intrapartum fetal compromise necessitating operative delivery. The addition of SVI, SVR or SVRI improved significantly the predictive accuracy of the baseline antenatal model. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.