The Challenge of p53: Linking Biochemistry, Biology, and Patient Management

Abnormalities of the p53 tumor suppressor gene are the single most common molecular abnormality seen in human cancer. Considerable evidence indicates that the product of this gene has critical roles in coordinating the response of cells to a diverse range of environmental stresses. At present, there...

Full description

Saved in:
Bibliographic Details
Published inStem cells (Dayton, Ohio) Vol. 16; no. 4; pp. 248 - 260
Main Authors Bray, Susan E., Schorl, Christoph, Hall, Peter A.
Format Journal Article
LanguageEnglish
Published Bristol John Wiley & Sons, Ltd 01.01.1998
Subjects
Animals
Biochemistry
Humans
p53
Physiology
Stress responses
Structure-Activity Relationship
Therapy
Tumor Suppressor Protein p53 - chemistry
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Protein p53 - physiology
Online AccessGet full text

Cover

More Information
Summary:Abnormalities of the p53 tumor suppressor gene are the single most common molecular abnormality seen in human cancer. Considerable evidence indicates that the product of this gene has critical roles in coordinating the response of cells to a diverse range of environmental stresses. At present, there is a gamut of biochemical properties and interactions ascribed to p53, but the in vivo physiological relevance of many of these remains uncertain. The development of clinical applications and novel therapeutic strategies utilizing our knowledge of p53 is contingent upon bridging the gap between rigorous biochemistry and holistic in vivo studies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1066-5099
1549-4918
DOI:10.1002/stem.160248