A long-term follow-up of ofloxacin-combined therapy to leprosy patients

• Published in: JAPANESE JOURNAL OF LEPROSY Vol. 76; no. 3; pp. 207 - 218
• Main Authors: OZAKI, Motoaki, ISHIKAWA, Makiko
• Format: Journal Article
• Language: Japanese
• Published: Japan Japanese Leprosy Association 01.09.2007
• Subjects: Aged; Anti-Bacterial Agents - administration & dosage; Clofazimine - administration & dosage; Cystamine - administration & dosage; Drug Therapy, Combination; follow-up; Follow-Up Studies; Humans; Leprostatic Agents - administration & dosage; leprosy; Leprosy - drug therapy; Male; Middle Aged; Minocycline - administration & dosage; multi-drug therapy; ofloxacin; Ofloxacin - administration & dosage; Rifampin - administration & dosage; therapeutic effect; Time Factors; Treatment Outcome
• ISSN: 1342-3681; 1884-314X
• DOI: 10.5025/hansen.76.207

This reports a long-term follow-up study on clinical effects of ofloxacin (OFLX)-combined therapy to 14 leprosy patients with various types and stages. Combined drugs were diaminodiphenyl sulfone(DDS), rifampicin (RFP) and clofazimine. Clinical evaluation of the treatment after OFLX-combined therapy was remarkable improvement 10 cases, improvement 3 and re-exacerbated after improvement 1 to whom clofazimine and minocycline were prescribed. The evaluation during the follow-up was remarkable improvement 10, improvement 1; three cases died of traffic accident or complications not related to chemotherapy and none of them showed relapse of leprosy. Bacterial negativity after onset of OFLX-combined therapy was achieved in about the same periods as RFP-combined therapy. OFLX-combined therapy was effective and safe. This follow-up study supports the efficacy of clinical guideline for the use of new quinolones published by Japanese leprosy Association.