Review of vascularized bone marrow transplantation: Current status and future clinical applications

• Published in: Microsurgery Vol. 27; no. 4; pp. 348 - 353
• Main Authors: Gordon, Chad R., Tai, Chau Y., Suzuki, Hidetoshi, Strande, Louise F., Ramsamooj, Rajendra, Matthews, Martha S., Black, Kirby S., Hewitt, Charles W.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 2007
• Subjects: Animals; Bone Marrow - blood supply; Bone Marrow Transplantation - immunology; Chimerism; Graft vs Host Disease - immunology; Graft vs Host Disease - prevention & control; Immune Tolerance; Immunosuppression - methods; Mice; Models, Animal; Stem Cell Transplantation; Transplantation, Isogeneic - immunology; Transplantation, Isogeneic - methods
• ISSN: 0738-1085; 1098-2752
• DOI: 10.1002/micr.20367

In this review, we examine the applicability of the vascularized bone marrow transplant (VBMT) as an alternative to conventional bone marrow transplantation (BMT). As a new surgical approach, the VBMT is unique by transplantation of the stromal environment that eliminates the need for an engraftment period, provides critical signaling and modulatory functions, and may potentiate tolerance induction. Thus far, VBMT studies have demonstrated an absence of graft‐versus‐host disease (GVHD) and robust engraftment into nonmanipulated as well as irradiated recipients with evidence of immunological tolerance. Further investigation is needed to determine the applicability of VBMT as an alternative to BMT. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.