Activation of an Endogenous Mouse Type C Virus by Ultraviolet-Irradiated Herpes Simplex Virus Types 1 and 2

Infection of BALB/c mouse cells with UV-irradiated herpes simplex virus (HSV) types 1 and 2 resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicit...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 73; no. 2; pp. 646 - 650
Main Authors Hampar, Berge, Aaronson, Stuart A., Derge, Jeffery G., Chakrabarty, Mrinal, Showalter, Stephen D., Dunn, Claire Y.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.02.1976
National Acad Sciences
Subjects
Cell Line
Cell lines
Cultured cells
Embryonic cells
Human herpesvirus 2
Infections
Kidney cells
Radiation Effects
Retroviridae - growth & development
Sarcoma
Simplexvirus
Simplexvirus - radiation effects
Ultraviolet Rays
Vero cells
Virus Replication
Viruses
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Summary:Infection of BALB/c mouse cells with UV-irradiated herpes simplex virus (HSV) types 1 and 2 resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat-inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3-4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.73.2.646