Diffuse optical tomography using multi-directional sources and detectors

• Published in: Biomedical optics express Vol. 7; no. 7; pp. 2623 - 2640
• Main Authors: Shimokawa, Takeaki, Ishii, Toshihiro, Takahashi, Yoichiro, Sugawara, Satoru, Sato, Masa-Aki, Yamashita, Okito
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 01.07.2016
• Subjects: (110.0113) Imaging through turbid media; (170.3880) Medical and biological imaging; (100.3010) Image reconstruction techniques
• ISSN: 2156-7085; 2156-7085
• DOI: 10.1364/boe.7.002623

Diffuse optical tomography (DOT) is an advanced imaging method used to visualize the internal state of biological tissues as 3D images. However, current continuous-wave DOT requires high-density probe arrays for measurement (less than 15-mm interval) to gather enough information for 3D image reconstruction, which makes the experiment time-consuming. In this paper, we propose a novel DOT measurement system using multi-directional light sources and multi-directional photodetectors instead of high-density probe arrays. We evaluated this system's multi-directional DOT through computer simulation and a phantom experiment. From the results, we achieved DOT with less than 5-mm localization error up to a 15-mm depth with low-density probe arrays (30-mm interval), indicating that the multi-directional measurement approach allows DOT without requiring high-density measurement.