Mutagenic effect of imidacloprid insecticide: The ameliorative effect of pre and post exposure to olive oil

• Published in: Journal of food biochemistry Vol. 44; no. 6; pp. e13221 - n/a
• Main Authors: Mohamed, Wafaa H., Amein, Karam A., Yahia, Doha, Sharkawy, Ahmed A., Mahmoud, Adel S.
• Format: Journal Article
• Language: English
• Published: United States 01.06.2020
• Subjects: chromosomal aberrations; imidacloprid; micronucleus assays; olive oil; chromosomal aberrations; olive oil; micronucleus assays; imidacloprid
• ISSN: 0145-8884; 1745-4514
• DOI: 10.1111/jfbc.13221

Imidacloprid, a systemic chloro–nicotinyl insecticide belong to neonicotinoid insecticides. In this study 120 rats were divided into four groups, the first group used as a control group, the second group was administered imidacloprid at a dose of 22.5 mg/kg b.w. for 4, 8, and 12 weeks. The third group was treated with olive oil (OLO) in a dose of 10 ml/kg body weight for 2 weeks before the oral dose of imidacloprid for 4, 8, and 12 weeks. The fourth group was given OLO in a dose of 10 ml/kg b.w. for 2 weeks after exposure to imidacloprid for 4, 8, and 12 weeks. Bone marrow was collected for micronucleus and chromosomal aberrations assays. The results revealed that imidacloprid induced a mutagenic effect in the 8th and 12th weeks of exposure and OLO decreased the mutagenic effect of imidacloprid in albino rats but not completely revert them to normal. Practical applications Using OLO as a protective or therapeutic agent due to it has an ameliorative effect on mutagenicity induced by IMI. Imidacloprid induced a mutagenic effect in the 8th and 12th weeks of exposure and olive oil decreased the mutagenic effect of imidacloprid in albino rats but not completely revert them to normal.