Malignant Rhabdoid Tumour in the Orbit of a Horse
A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneou...
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Published in | Journal of comparative pathology Vol. 121; no. 2; pp. 197 - 201 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.08.1999
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Subjects | |
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Abstract | A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneous tissues around the eye. The neoplasm was composed of polygonal cells with abundant eosinophilic cytoplasm. Many cells had a large, vesiculate, indented nucleus and contained a paranuclear globular inclusion. Ultrastructurally, the inclusions were seen to consist of whorls of intermediate filaments. The neoplastic cells were immunoreactive to vimentin and cytokeratin antisera, but were negative for desmin and actin. |
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AbstractList | A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneous tissues around the eye. The neoplasm was composed of polygonal cells with abundant eosinophilic cytoplasm. Many cells had a large, vesiculate, indented nucleus and contained a paranuclear globular inclusion. Ultrastructurally, the inclusions were seen to consist of whorls of intermediate filaments. The neoplastic cells were immunoreactive to vimentin and cytokeratin antisera, but were negative for desmin and actin. |
Author | Latimer, C.L. Hong, C.B. Van Meter, P.W. |
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Snippet | A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every... |
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SubjectTerms | Animals case studies eyes Female histopathology Horse Diseases - pathology Horses Immunohistochemistry Keratins - metabolism Lymphatic Metastasis - pathology malignant course metastasis neoplasms Orbital Neoplasms - metabolism Orbital Neoplasms - pathology Orbital Neoplasms - veterinary Rhabdoid Tumor - metabolism Rhabdoid Tumor - pathology Rhabdoid Tumor - veterinary Vimentin - metabolism |
Title | Malignant Rhabdoid Tumour in the Orbit of a Horse |
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