Malignant Rhabdoid Tumour in the Orbit of a Horse

• Published in: Journal of comparative pathology Vol. 121; no. 2; pp. 197 - 201
• Main Authors: Hong, C.B., Van Meter, P.W., Latimer, C.L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.1999
• Subjects: Animals; case studies; eyes; Female; histopathology; Horse Diseases - pathology; Horses; Immunohistochemistry; Keratins - metabolism; Lymphatic Metastasis - pathology; malignant course; metastasis; neoplasms; Orbital Neoplasms - metabolism; Orbital Neoplasms - pathology; Orbital Neoplasms - veterinary; Rhabdoid Tumor - metabolism; Rhabdoid Tumor - pathology; Rhabdoid Tumor - veterinary; Vimentin - metabolism
• DOI: 10.1053/jcpa.1999.0311
• ISSN: 0021-9975

A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneous tissues around the eye. The neoplasm was composed of polygonal cells with abundant eosinophilic cytoplasm. Many cells had a large, vesiculate, indented nucleus and contained a paranuclear globular inclusion. Ultrastructurally, the inclusions were seen to consist of whorls of intermediate filaments. The neoplastic cells were immunoreactive to vimentin and cytokeratin antisera, but were negative for desmin and actin.