Malignant Rhabdoid Tumour in the Orbit of a Horse

A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneou...

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Bibliographic Details
Published inJournal of comparative pathology Vol. 121; no. 2; pp. 197 - 201
Main Authors Hong, C.B., Van Meter, P.W., Latimer, C.L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.1999
Subjects
Animals
case studies
eyes
Female
histopathology
Horse Diseases - pathology
Horses
Immunohistochemistry
Keratins - metabolism
Lymphatic Metastasis - pathology
malignant course
metastasis
neoplasms
Orbital Neoplasms - metabolism
Orbital Neoplasms - pathology
Orbital Neoplasms - veterinary
Rhabdoid Tumor - metabolism
Rhabdoid Tumor - pathology
Rhabdoid Tumor - veterinary
Vimentin - metabolism
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Summary:A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneous tissues around the eye. The neoplasm was composed of polygonal cells with abundant eosinophilic cytoplasm. Many cells had a large, vesiculate, indented nucleus and contained a paranuclear globular inclusion. Ultrastructurally, the inclusions were seen to consist of whorls of intermediate filaments. The neoplastic cells were immunoreactive to vimentin and cytokeratin antisera, but were negative for desmin and actin.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0021-9975
1532-3129
DOI:10.1053/jcpa.1999.0311