Phage Therapy: Consider the Past, Embrace the Future

Antibiotic-resistant bacteria infections pose a threat to public health. Considering the difficulty in developing new antibiotics, it is an urgent need to develop alternative therapies against bacterial pathogens. Bacteriophages (phages) are evaluated as potential substitutes or adjuncts of antibiot...

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Bibliographic Details
Published inApplied sciences Vol. 10; no. 21; p. 7654
Main Authors Wei, Junwei, Peng, Nan, Liang, Yunxiang, Li, Keke, Li, Yingjun
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2020
Subjects
antibiotic resistance
Antibiotics
Bacteria
Bacterial infections
CRISPR-Cas
Drug resistance
Infections
Mutation
Pathogens
phage engineering
phage therapy
Phage-antibiotic synergy
Physiology
Plant diseases
Prevention
Virulence
United States > US
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Summary:Antibiotic-resistant bacteria infections pose a threat to public health. Considering the difficulty in developing new antibiotics, it is an urgent need to develop alternative therapies against bacterial pathogens. Bacteriophages (phages) are evaluated as potential substitutes or adjuncts of antibiotics because they are abundant in nature and could specifically lyse bacteria. In this review, we briefly introduce phage therapy and its advantages compared with traditional antibiotic therapy. We also summarize new emerging phage technologies, such as CRISPR-Cas, synthetic phages, etc., and discuss some possible obstacles and potential risks in the application process. We believe that, with the advancement in synthetic biology and delivery technology, phage therapy has broad prospects in the future.
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ISSN:2076-3417
2076-3417
DOI:10.3390/app10217654